CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin S

Enzyme Information

3.4.22.15
Cathepsin L.
based on mapping to UniProt P07711
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity.
-!- A lysosomal enzyme that is readily inhibited by the diazomethane inhibitor Z-Phe-Phe-CHN(2) or the epoxide inhibitor E-64. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07711
CATL1_HUMAN
Homo sapiens
Cathepsin L1

PDB Structure

PDB 3H8B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A combined crystallographic and molecular dynamics study of cathepsin L retrobinding inhibitors
Shenoy, R.T., Chowdhury, S.F., Kumar, S., Joseph, L., Purisima, E.O., Sivaraman, J.
J.Med.Chem.