CATH Classification

Domain Context

CATH Clusters

Superfamily 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1
Functional Family 2,3-dihydroxybiphenyl 1,2-dioxygenase

Enzyme Information

1.13.11.25
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5- dioxygenase.
based on mapping to UniProt P9WNW7
3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O(2) = 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate.
-!- Also acts on 3-isopropylcatechol and 3-tert-butyl-5-methylcatechol.

UniProtKB Entries (1)

P9WNW7
HSAC_MYCTU
Mycobacterium tuberculosis H37Rv
Iron-dependent extradiol dioxygenase

PDB Structure

PDB 2ZI8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis.
Yam, K.C., D'Angelo, I., Kalscheuer, R., Zhu, H., Wang, J.X., Snieckus, V., Ly, L.H., Converse, P.J., Jacobs, W.R., Strynadka, N., Eltis, L.D.
Plos Pathog.