CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase P

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P09211
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P09211
GSTP1_HUMAN
Homo sapiens
Glutathione S-transferase P

PDB Structure

PDB 1ZGN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo
Cesareo, E., Parker, L.J., Pedersen, J.Z., Nuccetelli, M., Mazzetti, A.P., Pastore, A., Federici, G., Caccuri, A.M., Ricci, G., Adams, J.J., Parker, M.W., Bello, M.L.
J.Biol.Chem.