CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family cAMP-dependent protein kinase catalytic subunit alpha

Enzyme Information

2.7.11.11
cAMP-dependent protein kinase.
based on mapping to UniProt P00517
ATP + a protein = ADP + a phosphoprotein.
-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P00517
KAPCA_BOVIN
Bos taurus
CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB 1VEB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure-based optimization of novel azepane derivatives as PKB inhibitors
Breitenlechner, C.B., Wegge, T., Berillon, L., Graul, K., Marzenell, K., Friebe, W.-G., Thomas, U., Schumacher, R., Huber, R., Engh, R.A., Masjost, B.
J.Med.Chem.