CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.2020
Functional Family Orotate phosphoribosyltransferase

Enzyme Information

2.4.2.10
Orotate phosphoribosyltransferase.
based on mapping to UniProt P0A7E3
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- The enzyme from higher eukaryotes also catalyzes the reaction listed as EC 4.1.1.23.

UniProtKB Entries (1)

P0A7E3
PYRE_ECOLI
Escherichia coli K-12
Orotate phosphoribosyltransferase

PDB Structure

PDB 1ORO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase.
Henriksen, A., Aghajari, N., Jensen, K.F., Gajhede, M.
Biochemistry