CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cytochrome P450 2A6

Enzyme Information

1.14.14.1
Unspecific monooxygenase.
based on mapping to UniProt P00179
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. -!- Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH. -!- Some of the reactions attributed to EC 1.14.15.3 belong here. -!- Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.

UniProtKB Entries (1)

P00179
CP2C5_RABIT
Oryctolagus cuniculus
Cytochrome P450 2C5

PDB Structure

PDB 1NR6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of Mammalian Cytochrome P450 2C5 Complexed with Diclofenac at 2.1 A Resolution: Evidence for an Induced Fit Model of Substrate Binding
WESTER, M.R., JOHNSON, E.F., Marques-Soares, C., Dijols, S., Dansette, P.M., Mansuy, D., STOUT, C.D.
Biochemistry