CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Thymidylate kinase |
Enzyme Information
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt P9WKE1
ATP + dTMP = ADP + dTDP.
|
UniProtKB Entries (1)
| P9WKE1 |
KTHY_MYCTU
Mycobacterium tuberculosis H37Rv
Thymidylate kinase
|
PDB Structure
| PDB | 1MRS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.
J.Biol.Chem.
|