CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P16184
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P16184
DYR_PNECA
Pneumocystis carinii
Dihydrofolate reductase

PDB Structure

PDB 1LY4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase.
Cody, V., Galitsky, N., Luft, J.R., Pangborn, W., Queener, S.F., Gangjee, A.
Acta Crystallogr.,Sect.D