CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Primary amine oxidase

Enzyme Information
Primary-amine oxidase.
based on mapping to UniProt P46883
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC

UniProtKB Entries (1)

Escherichia coli K-12
Primary amine oxidase

PDB Structure

External Links
Organism Escherichia
Primary Citation
Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine.
Wilmot, C.M., Saysell, C.G., Blessington, A., Conn, D.A., Kurtis, C.R., McPherson, M.J., Knowles, P.F., Phillips, S.E.
Febs Lett.