CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Glycerol kinase

Enzyme Information

2.7.1.30
Glycerol kinase.
based on mapping to UniProt P0A6F3
ATP + glycerol = ADP + sn-glycerol 3-phosphate.
-!- Glycerone and L-glyceraldehyde can act as acceptors. -!- UTP (and, in the case of the Saccharomyces cerevisiae enzyme, ITP and GTP) can act as donors.

UniProtKB Entries (1)

P0A6F3
GLPK_ECOLI
Escherichia coli K-12
Glycerol kinase

PDB Structure

PDB 1GLL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of Escherichia coli glycerol kinase variant S58-->W in complex with nonhydrolyzable ATP analogues reveal a putative active conformation of the enzyme as a result of domain motion.
Bystrom, C.E., Pettigrew, D.W., Branchaud, B.P., O'Brien, P., Remington, S.J.
Biochemistry