CATH Classification

Domain Context

CATH Clusters

Superfamily Ubiquitin Conjugating Enzyme
Functional Family Ubiquitin-conjugating enzyme E2 L3

Enzyme Information

2.3.2.23
E2 ubiquitin-conjugating enzyme.
based on mapping to UniProt P68036
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine.
-!- The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself. -!- In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage. -!- Formerly EC 6.3.2.19.

UniProtKB Entries (1)

P43403
ZAP70_HUMAN
Homo sapiens
Tyrosine-protein kinase ZAP-70

PDB Structure

PDB 1FBV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Zheng, N., Wang, P., Jeffrey, P.D., Pavletich, N.P.
Cell(Cambridge,Mass.)