CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family N-acetylneuraminate lyase

Enzyme Information

4.1.3.3
N-acetylneuraminate lyase.
based on mapping to UniProt P44539
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
-!- Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.

UniProtKB Entries (1)

P44539
NANA_HAEIN
Haemophilus influenzae Rd KW20
N-acetylneuraminate lyase

PDB Structure

PDB 1F73
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
Barbosa, J.A.R.G., Smith, B.J., DeGori, R., Ooi, H.C., Marcuccio, S.M., Campi, E.M., Jackson, W.R., Brossmer, R., Sommer, M., Lawrence, M.C.
J.Mol.Biol.