CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family GDP-L-fucose synthase

Enzyme Information

1.1.1.271
GDP-L-fucose synthase.
based on mapping to UniProt P32055
GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH.
-!- Both human and Escherichia coli enzymes can use NADH in place of NADPH to a slight extent.

UniProtKB Entries (1)

P32055
FCL_ECOLI
Escherichia coli K-12
GDP-L-fucose synthase

PDB Structure

PDB 1E7R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Probing the Catalytic Mechanism of Gdp-4-Keto-6-Deoxy-D-Mannose Epimerase/Reductase by Kinetic and Crystallographic Characterization of Site-Specific Mutants
Rosano, C., Bisso, A., Izzo, G., Tonetti, M., Sturla, L., De Flora, A., Bolognesi, M.
J.Mol.Biol.