CATH Classification

Domain Context

CATH Clusters

Superfamily Ferredoxin thioredoxin reductase catalytic beta subunit
Functional Family Ferredoxin-thioredoxin reductase, catalytic chain

Enzyme Information

1.8.7.2
Ferredoxin:thioredoxin reductase.
based on mapping to UniProt Q55389
2 reduced ferredoxin + thioredoxin disulfide = 2 oxidized ferredoxin + thioredoxin + 2 H(+).
-!- The enzyme contains a [4Fe-4S] cluster and internal disulfide. -!- It forms a mixed disulfide with thioredoxin on one side, and docks ferredoxin on the other side, enabling two one-electron transfers. -!- The reduced thioredoxins generated by the enzyme activate the Calvin cycle enzymes EC 3.1.3.11, EC 3.1.3.37 and EC 2.7.1.19 as well as other chloroplast enzymes by disulfide reduction.

UniProtKB Entries (1)

Q55389
FTRC_SYNY3
Synechocystis sp. PCC 6803 substr. Kazusa
Ferredoxin-thioredoxin reductase, catalytic chain

PDB Structure

PDB 1DJ7
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Redox signaling in chloroplasts: cleavage of disulfides by an iron-sulfur cluster.
Dai, S., Schwendtmayer, C., Schurmann, P., Ramaswamy, S., Eklund, H.
Science