CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family 8-amino-7-oxononanoate synthase

Enzyme Information

2.3.1.47
8-amino-7-oxononanoate synthase.
based on mapping to UniProt P12998
Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].
-!- The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. -!- Pimeloyl-CoA can be used with lower efficiency.

UniProtKB Entries (1)

P12998
BIOF_ECOLI
Escherichia coli K-12
8-amino-7-oxononanoate synthase

PDB Structure

PDB 1BS0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme.
Alexeev, D., Alexeeva, M., Baxter, R.L., Campopiano, D.J., Webster, S.P., Sawyer, L.
J.Mol.Biol.