CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase beta-2

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt P20231
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231
TRYB2_HUMAN
Homo sapiens
Tryptase beta-2

PDB Structure

PDB 1A0L
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.
Pereira, P.J., Bergner, A., Macedo-Ribeiro, S., Huber, R., Matschiner, G., Fritz, H., Sommerhoff, C.P., Bode, W.
Nature