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CATH Superfamily 3.40.50.620

HUPs

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
HUPs
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 86531: Probable cysteine--tRNA ligase, mitochondrial

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase. [EC: 6.3.1.13]
1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol + L-cysteine + ATP = 1-O-(2-(L-cysteinamido)-2-deoxy-alpha-D-glucopyranosyl)-1D-myo- inositol + AMP + diphosphate.
  • This enzyme is a key enzyme in the biosynthesis of mycothiol, a small molecular weight thiol found in Mycobacteria spp. and other actinomycetes.
  • Mycothiol plays a fundamental role in these organisms by helping to provide protection from the effects of reactive oxygen species and electrophiles, including many antibiotics.
  • The enzyme may represent a novel target for new classes of antituberculars.
  • Formerly EC 6.1.1.n1.
 2542 A0A010NQ76 A0A010NQ76 A0A014MEL2 A0A014MEL2 A0A021VX71 A0A021VX71 A0A022KYX4 A0A022KYX4 A0A022LJW7 A0A022LJW7
(2532 more...)
Cysteine--tRNA ligase. [EC: 6.1.1.16]
ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys).
    		 480 A0A023B4N4 A0A023B4N4 A0A024RCG3 A0A024RCG3 A0A024V773 A0A024V773 A0A024VR85 A0A024VR85 A0A024W6A4 A0A024W6A4
    (470 more...)
    D-alanine--poly(phosphoribitol) ligase. [EC: 6.1.1.13]
    ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D- alanyl-poly(ribitol phosphate).
    • A thioester bond is formed transiently between D-alanine and the sulfhydryl group of the 4'-phosphopantetheine prosthetic group of D-alanyl carrier protein during the activation of the alanine.
    • Involved in the synthesis of teichoic acids.
    		 16 A0A1L7CFX0 A0A1L7CFX0 A0A1L7CLY7 A0A1L7CLY7 A0A1L7CSK3 A0A1L7CSK3 A0A1L7CY21 A0A1L7CY21 A0A1L7D341 A0A1L7D341
    (6 more...)
    2-alkenal reductase (NAD(P)(+)). [EC: 1.3.1.74]
    A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H.
    • Highly specific for 4-hydroxynon-2-enal and non-2-enal.
    • Alk-2-enals of shorter chain have lower affinities.
    • Exhibits high activities also for alk-2-enones such as but-3-en-2-one and pent-3-en-2-one.
    • Inactive with cyclohex-2-en-1-one and 12-oxophytodienoic acid.
    • Involved in the detoxification of alpha,beta-unsaturated aldehydes and ketones (cf. EC 1.3.1.102).
    		 2 B7PNE2 B7PNE2
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