×

Network disruptions

We have been experiencing disruptions on our local network which has affected the stability of these web pages. We have been working with IT support team to get this fixed as a matter of urgency and apologise for any inconvenience.

View in Gene3D

CATH Superfamily 6.20.260.10

Adenylylsulphate reductase, beta subunit, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Adenylylsulphate reductase, beta subunit, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Adenylylsulphate reductase, beta subunit, C-terminal domain

The iron-sulfur flavoenzyme adenylylsulfate (adenosine 5'-phosphosulfate, APS) reductase catalyzes reversibly the reduction of APS to sulfite and AMP. It consists of two different subunits, alpha and beta, that are arranged as an alpha2beta2 heterotetramer. The alpha-subunit harbors the FAD cofactor and comprises an FAD-binding, a helical, and a capping domain; each of them an alpha/beta structure. This overall architecture classifies APS reductase as member of the fumarate reductase family.

The beta subunit consists of a bacterial ferredoxin-like segment carrying two [4Fe-4S] clusters, a three-stranded antiparallel beta-sheet, and a tail. Structural domains comprising this superfamily share the structure of the C-terminal region of this subunit which includes the beta-sheet and the C-terminal tail PMID:16503650,PMID:19820092,PMID:11842205.

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
410 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 18
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO: 6
Taxonomy
Unique Species: 410
CATH-Gene3D is a Global Biodata Core Resource Learn more...