The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Ribosomal protein L10e/L16

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Ribosomal protein L16/L10

This superfamily entry contains the ribosomal protein L16 found in the 50S subunit of the bacterial, mitochondrial and plastid ribosome, as well as its eukaryotic and archaeal homologue found in the 60S subunit, L10 (or RPL10). L16 and L10e exhibit structural differences, especially at the N-terminal region. This structural domain exhibits an alpha/beta-hammerhead fold, where the beta-hammerhead motif is similar to that in barrel-sandwich hybrids. L10 and L16 contribute to the architecture of the tRNA binding site on the large ribosomal subunit.

Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit, binding of aminoacyl-tRNA and interaction with antibiotics. L16 is required for the function of elongation factor P (EF-P), a protein involved in peptide bond synthesis through the stimulation of peptidyl transferase activity by the ribosome. All known mutations in L16 confer antibiotic resistance in bacteria (such as resistance to avilamycin and evernimicin), suggesting a direct participation of L16 in the binding site for antibiotics. The GTPase RbgA (YlqF) is essential for the assembly of the large subunit, and it is believed to regulate the incorporation of L16.

Additionally, L10 exhibits other cellular activities, in particular the human L10 which works as a tumour suppressor (QM). Studies in yeast have shown that L10 incorporation is a prerequisite for ribosomal subunit joining and translation initiation, and it also represents a key step for the nuclear export of the large ribosomal subunit.

PFAM:PF00252, INTERPRO:IPR036920,PMID:15561149,PMID:12384386,PMID:18258260

GO Diversity

Unique GO annotations
61 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
21022 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 402
Domain clusters (>95% seq id): 17
Domain clusters (>35% seq id): 5
Unique PDBs: 401
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 35
Unique EC:
Unique GO: 61
Unique Species: 21022