The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

D-Ala-D-Ala carboxypeptidase C, peptidase S13

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: D-Ala-D-Ala carboxypeptidase C, peptidase S13

Structural domains comprising this superfamily share the structure of the MEROPS peptidase family S13 (D-Ala-D-Ala carboxypeptidase C, clan SE). D-Ala-D-Ala carboxypeptidase C is involved in the metabolism of cell components PMID:1741619 and it is synthesised with a leader peptide which targets it to the cell membrane PMID:7845208. After cleavage of the leader peptide, the enzyme is retained in the membrane by a C-terminal anchor PMID:7845208. There are three families of serine-type D-Ala-D-Ala peptidase (designated S11, S12 and S13), which are also known as low molecular weight penicillin-binding proteins PMID:7845208. Family S13 comprises D-Ala-D-Ala peptidases that have sufficient sequence similarity around their active sites to assume a distant evolutionary relationship to other clan members; members of the S13 family also bind penicillin and have D-amino-peptidase activity. Proteases of family S11 have exclusive D-Ala-D-Ala peptidase activity, while some members of S12 are C beta-lactamases PMID:7845208.

GO Diversity

Unique GO annotations
15 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
4458 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 108
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 3
Unique PDBs: 37
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC: 1
Unique GO: 15
Unique Species: 4458