The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Janus/Ocnus
".
3.50.20.20
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: Janus/Ocnus
Structural domains comprising this superfamily share the structure of the 14 kDa phosphohistidine phosphatase from mammals (PHPT1) and Janus-A/Janus-B proteins from Drosophila melanogaster. The PHPT1 DNA sequence shows similarity to testes-specific proteins in Drosophila, ocnus, Janus-A, and Janus-B. These proteins may be phosphatases, but there is little available information on their function. The 14 kDa phosphohistidine phosphatase is of a novel topology, and the structure reveals a positively charged active site defined by conserved residues that provide a suitable environment for binding phosphohistidine-containing substrates PMID:16990267. It is thought that this protein may play a role of reversible histidine phosphorylation in neuronal functions PMID:12468887.
GO Diversity
Unique GO annotations
16 Unique GO terms
EC Diversity
Unique EC annotations
1 Unique EC terms
Species Diversity
Unique species annotations
461 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 7 |
| Domain clusters (>95% seq id): | 1 |
| Domain clusters (>35% seq id): | 1 |
| Unique PDBs: | 5 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 9 |
| Function | |
| Unique EC: | 1 |
| Unique GO: | 16 |
| Taxonomy | |
| Unique Species: | 461 |
