The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

The influenza virus contains a segmented RNA genome with eight negative-sense segments encoding 11 proteins. The influenza virus polymerase is a heterotrimeric complex comprised by the protein subunits: PA, PB1, and PB2. It plays central roles in the viral life cycle and is directly responsible for RNA synthesis for both viral replication and transcription.

The PA subunit can be cleaved into two independent domains: a smaller N-terminal domain with cap-dependent endonuclease activity and a larger C-terminal domain that mediates the interaction with PB1. Structural domains comprising this superfamily share the structure of the N-terminal endonuclease domain of PA PMID:19587036,PMID:22876177,PMID:26976575.

GO Diversity

Unique GO annotations
15 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
6385 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 157
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 3
Unique PDBs: 83
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 15
Unique Species: 6385