The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Leucyl/phenylalanyl-tRNA-protein transferase, C-terminal domain

Structural domains comprising this superfamily share the structure of the C-terminal domain of leucyl/phenylalanyl-tRNA-protein transferases (L/F-transferases), an N-end rule pathway enzyme, involved in the transfer of Leu and Phe from aminoacyl-tRNAs to exposed N-terminal Arg or Lys residues of acceptor proteins PMID:17891155. This C-terminal domain has a highly conserved fold, observed in the GCN5-related N-acetyltransferase (GNAT) family.

The interface of the N-terminal and C-terminal domains forms a large central cavity, with the characteristic positive charge contributed by the corner of the cleft on the C-terminal domain surface, suggesting that they probably complement the negatively charged phosphate backbone of the substrate aminoacyl-tRNA PMID:17242373.

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
6185 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 17
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 9
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 11
Unique EC: 1
Unique GO: 6
Unique Species: 6185