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CATH Superfamily 3.40.50.11730

Peroxisome assembly protein 22

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Peroxisome assembly protein 22
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Peroxisome assembly protein 22

This superfamily includes the peroxin-22, an integral peroxisomal membrane protein. The N-terminus of peroxin-22 is located in the matrix, while the C-terminus is located in the cytosol. Peroxin-22 interacts with the ubiquitin-conjugating enzyme Pex4p, anchoring it at the peroxisomal membrane. Both proteins may act at the same step in peroxisome biogenesis. The presence of Pex22p may therefore allow for site-specific ubiquitination of the conserved cysteine, by correct positioning of Pex4p in relation to the exposed N-terminus of Pex5p.

INTERPRO:IPR024359,DOI:10.1038/emboj.2011.411

GO Diversity

Unique GO annotations
9 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
86 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 4
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Function
Unique EC:
Unique GO: 9
Taxonomy
Unique Species: 86