The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Toll/interleukin-1 receptor homology (TIR) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
566
3D
1o77E00 - 96.4
2
433 - - 98.7
3
311 - - 92.7
4
240
3D
1t3gB00 - 64.1
5
154
3D
4eo7A01 - 88.0
7
TIR-NBS-LRR class
154
3D
5tecB00 - 95.3
6
140 - - 80.3
8
95 - - 88.7
9
86 - - 93.2
10
83
3D
5forA00 - 89.6
11
78 - - 57.9
12
73 - - 53.8
13
65 - - 39.5
14
59 - - 67.1
15
53
3D
4lqdA00 - 40.3
17
46 - - 93.7
16
TIR-NBS class
46 - - 72.0
18
45 - - 65.7
19
43 - - 71.5
20
40 - - 80.3
21
35 - - 89.1
22
23 - - 85.1
23
19 - - 37.5
25
TIR-NBS-LRR class
18
3D
4c6tC00 - 87.9
24
18
3D
2m1xA00 - 64.2
26
15 - - 92.4
27
14 - - 14.4
28
10 - - 0.8
29
Drosophila
9 - - 3.5
31
8 - - 12.1
30
8 - - 76.0
36
6
3D
4lzpC00 - 0.7
33
6 - - 23.6
32
6 - - 12.8
35
5 - - 22.1
34
5 - - 59.0
39
4 - - 44.9
40
4 - - 59.1
37
TIR-NBS-LRR class
4 - - 0.0
38
4 - - 12.9
41
3 - - 70.6
43
3 - - 6.2
44
3 - - 3.1
42
3 - - 0.0
61
2 - - 0.7
48
2 - - 9.7
55
2 - - 3.8
60
2 - - 0.0
63
2 - - 40.3
62
2 - - 0.0
49
2 - - 3.3
50
2 - - 26.7
56
2 - - 0.0
58
2 - - 0.0
51
2 - - 34.6
57
TIR-NBS-LRR class
2 - - 0.0
46
2 - - 1.5
64
2 - - 41.5
45
2 - - 0.0
52
2 - - 44.2
53
2 - - 5.5
59
TIR-NBS class
2 - - 0.0
47
2 - - 11.3
54
2 - - 0.8
78
1 - - 0.0
89
1 - - 0.0
91
1 - - 0.0
68
1 - - 0.0
80
1 - - 0.0
92
1 - - 0.0
82
1 - - 0.0
69
1 - - 0.0
90
1 - - 0.0
81
1 - - 0.0
76
1 - - 0.0
84
1 - - 0.0
77
1 - - 0.0
79
1 - - 0.0
93
1 - - 0.0
83
1 - - 0.0
70
1 - - 0.0
71
1 - - 0.0
96
1 - - 0.0
85
1 - - 0.0
74
1 - - 0.0
94
1 - - 0.0
95
1 - - 0.0
65
1 - - 0.0
86
1 - - 0.0
75
1 - - 0.0
87
1 - - 0.0
66
1 - - 0.0
72
1 - - 0.0
73
1 - - 0.0
67
1 - - 0.0
88
1 - - 0.0