The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Nsp3, SUD-M subdomain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Nsp3, SUD-M subdomain

Non-structural protein 3 (Nsp3) contains at least seven different functional modules within its 1922-amino-acid polypeptide chain. One of these is the so-called SARS(severe acute respiratory syndrome)-unique domain (SUD), a stretch of about 338 residues that is completely absent from any other coronavirus. The SUD domain may be responsible for the high pathogenicity of the SARS coronavirus, compared to other viruses of this family.

SUD(core) exhibits a two-domain architecture. The N-terminal subdomain (SUD-N) comprises Nsp3 residues 389-517, and the C-terminal subdomain of SUDcore contains residues 525-652, also named "middle SUD subdomain", or SUD-M.

This superfamily entry is represented by the middle SUD subdomain. SUD-M binds single-stranded poly(A); the contact area with this RNA on the protein surface, and the electrophoretic mobility shift assays confirm that SUD-M has higher affinity for purine bases than for pyrimidine bases PMID:19052085.

PFAM:PF11633, INTERPRO:IPR024375,DOI:10.1371/journal.ppat.1000428,DOI:10.1128/JVI.01781-08

GO Diversity

Unique GO annotations
3 Unique GO terms

EC Diversity

Unique EC annotations
5 Unique EC terms

Species Diversity

Unique species annotations
58 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 13
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 9
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 2
Unique EC: 5
Unique GO: 3
Unique Species: 58