The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Cypl, domain I
".
3.40.190.180
superfamily
Functional Families
Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
Superfamily: Cypl, domain I
This superfamily contains domain I of Cypl (extracytoplasmic thiamine-binding lipoprotein). Literature suggests that the high affinity transport system protein p37 specific to Mycoplasma species (as it currently appears in pfam and InterPro entries) was renamed the extracytoplasmic thiamine-binding lipoprotein. The p37 gene is part of an operon encoding two additional proteins which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria. It has been suggested that p37 is part of a homologous, high-affinity transport system in M. hyorhinis, a Gram-positive bacterium. Its structure indicates that it is a thiamine pyrophosphate-binding protein.
The monomer is a mixed alpha/beta fold split into two globular domains (Domains I and II) connected by two linker regions and the C-terminal helix. This entry represents Domain I, which consists of a six-stranded beta-sheet flanked by seven helices.
PFAM:PF06646, INTERPRO:IPR010592,DOI:10.1128/JB.01680-08,DOI:10.1002/prot.22900
GO Diversity
Unique GO annotations
4 Unique GO terms
EC Diversity
Unique EC annotations
0 Unique EC terms
Species Diversity
Unique species annotations
69 Unique species
Sequence/Structure Diversity
Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.
Superfamily Summary
A general summary of information for this superfamily.
| Structures | |
|---|---|
| Domains: | 5 |
| Domain clusters (>95% seq id): | 2 |
| Domain clusters (>35% seq id): | 2 |
| Unique PDBs: | 4 |
| Alignments | |
| Structural Clusters (5A): | 1 |
| Structural Clusters (9A): | 1 |
| FunFam Clusters: | 1 |
| Function | |
| Unique EC: | |
| Unique GO: | 4 |
| Taxonomy | |
| Unique Species: | 69 |
