The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, catalytic domain

According to the literature, structural domains which comprise this superfamily correspond to the structure of domain 3 in 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, IspH (LytB). This iron-sulphur enzyme catalyses the final step of the methylerythritol phosphate (MEP) isoprenoid biosynthesis pathway which gives rise to the universal precursors of terpenes: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). This pathway has been identified in many bacteria as well as algae and the chloroplasts of higher plants.

IspH is a monomeric enzyme comprised on 3-domains, all of which share a similar structure and, although there is no specific information related to the function of each domain, it seems like all of them are involved in the catalytic process.

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
10253 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 118
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 5
Unique PDBs: 30
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 6
Unique EC: 1
Unique GO: 10
Unique Species: 10253