The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Elongation factor 4, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Elongation factor 4, C-terminal domain

This superfamily entry represents the unique C-terminal domain (CTD) of elongation factor 4 (LepA or GUF1 in Saccaromyces), a GTP-binding membrane protein related to EF-G and EF-Tu. LepA is a noncanonical GTPase that promotes the back translocation of tRNAs on the ribosome during the elongation cycle. It is highly conserved and present in bacteria, mitochondria, and chloroplasts PMID:28320876. LepA contains domains that are homologous to EF-G domain I, II, III, V. However, it also contains a C-terminal domain (CTD) that is not homologous to any region in EF-G. The CTD of LepA may play a primary role in back translocation by providing additional binding interactions with a back-translocated tRNA PMID:18362332.

PFAM:PF06421, INTERPRO:IPR013842,DOI:10.1073/pnas.0801308105

GO Diversity

Unique GO annotations
24 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
12828 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 10
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Unique EC: 1
Unique GO: 24
Unique Species: 12828