The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"KRIT, N-terminal Nudix domain, NPxY motif-rich region
".
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"This superfamily entry describes the N-terminal domain, which adopts a Nudix fold, carries three NPxY-like motifs and is found to bind the integrin cytoplasmic-associated protein 1 (ICAP1). In the absence of KRIT1, ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via this domain out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented PMID:23317506. KRIT1 does not include the canonical "Nudix box" motif or other Nudix motifs but does, however, very clearly adopt a Nudix fold with a central beta-sheet flanked by two alpha-helices.
INTERPRO:IPR032022 , PFAM:PF16705,DOI:10.1016/j.molcel.2012.12.005
Structures | |
---|---|
Domains: | 4 |
Domain clusters (>95% seq id): | 2 |
Domain clusters (>35% seq id): | 2 |
Unique PDBs: | 1 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 2 |
Function | |
Unique EC: | |
Unique GO: | 30 |
Taxonomy | |
Unique Species: | 177 |