The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Spike protein, C-terminal core receptor binding subdomain

The newly-emerging Middle East respiratory syndrome coronavirus (MERS-CoV) can cause severe and fatal acute respiratory disease in humans. Despite global efforts, the potential for an associated pandemic in the future cannot be excluded. Since September 2012, 1,368 laboratory-confirmed cases of human infection by the Middle East respiratory syndrome coronavirus (MERS-CoV) have officially been reported to World Health Organization as of 17 July 2015, including at least 490 related deaths with a fatality rate of ~35.8%.

MERS-CoV belongs to the beta-genus and uses human dipeptidyl peptidase 4 (DPP4) as its host receptor. Receptor recognition is a major determinant of coronavirus host range and tropism. An envelope-anchored trimeric spike protein is responsible for coronavirus entry into host cells via binding to the host receptor and subsequently fusing viral and host membranes. The spike protein consists of a receptor-binding S1 subunit and a membrane fusion S2 subunit. The S1 subunit consists of an N-terminal and a C-terminal domain, both of which can function as receptor-binding domains (RBD). However, it is the C-domain that interacts with DPP4.

This entry represents the core-subdomain of the RBD which is a five-stranded antiparallel beta-sheet with several short alpha-helices.

PMID:23903833 PMID:26391698

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
121 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 58
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 2
Unique PDBs: 28
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 3
Unique EC:
Unique GO: 10
Unique Species: 121