The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Lsr2, dimerization domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Lsr2, dimerisation domain

Bacterial nucleoid-associated proteins play important roles in chromosome organization and global gene regulation. Lsr2 of Mycobacterium tuberculosis is a unique nucleoid-associated protein that binds AT-rich regions of the genome, including genomic islands acquired by horizontal gene transfer and regions encoding major virulence factors. Domain swapping experiments reveal that Lsr2 has an N-terminal dimerisation domain and a C-terminal DNA-binding domain. This entry represents the dimerisation domain of Lsr2

Besides enabling dimerisation of Lsr2 monomers, structural studies on the N-terminal domain have shown that Lsr2 dimers show a self-associative propensity allowing chromosome compaction and gene regulation in response to external stress PMID:20133735

GO Diversity

Unique GO annotations
10 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
2150 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 2
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 10
Unique Species: 2150