The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Gnk2 domain, C-X8-C-X2-C motif

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Gnk2 domain, C-X8-C-X2-C motif

This superfamily represents the domain of Gnk2, composed of two alpha-helices and a five-stranded beta-sheet, which formed a compact single-domain architecture with an alpha+beta-fold. Ginkbilobin-2 (Gnk2) is an antifungal protein found in the endosperm of Ginkgo seeds, which inhibits the growth of phytopathogenic fungi such as Fusarium oxysporum. the proteins with a Gnk2-homologous domain are regarded as one of the largest protein superfamilies, although the role of the conserved Gnk2-homologous domain remains unclear PMID:19603485,PMID:11402176.

This entry describes the Gnk2 domain containing a C-X8-C-X2-C motif, which accounts for the similarity with the extracellular domain of cysteine-rich receptor-like kinases (CRK) (28-31% identical sequence). The domain has a role in salt stress response and has antifungal activity.

PFAM:PF01657, INTERPRO:IPR002902,DOI:10.1002/prot.22494

GO Diversity

Unique GO annotations
35 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
143 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 73
Unique EC: 1
Unique GO: 35
Unique Species: 143