The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Arenaviral nucleoprotein, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Arenaviral nucleoprotein, C-terminal domain

Arenaviridae are single stranded RNA viruses. The arenaviridae S RNAs that have been characterised include conserved terminal sequences, an ambisense arrangement of the coding regions for the precursor glycoprotein (GPC) and nucleocapsid (N) proteins and an intergenic region capable of forming a base-paired "hairpin" structure. The mature glycoproteins that result are G1 and G2 and the N protein PMID:2042397.

The representative domain of this superfamily entry was characterised in lassa fever virus (LASV), a member of the family Arenaviridae, which causes severe hemorrhagic fever and is highly endemic in Western Africa.

The arenaviral nucleoprotein NP has been implicated in suppression of the host innate immune system. The NP encapsulates the viral ssRNA PMID:8599223.

This N-terminal domain folds into a novel structure with a deep cavity for binding the m7GpppN cap structure that is required for viral RNA transcription PMID:21085117. The C-terminal domain has 3'-5' exoribonuclease activity and is involved in suppressing interferon induction PMID:21085117. It forms a typical alpha/beta/alpha sandwich architecture and contains a CCHE zinc-binding site near the 3'-5' exonuclease active site.

PFAM:PF00843, INTERPRO:IPR000229,DOI:10.1073/pnas.1016404108,DOI:10.1038/nature09605

GO Diversity

Unique GO annotations
6 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
65 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 23
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 13
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 6
Unique Species: 65