The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

DNA repair protein Rad52/59/22

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: DNA repair protein Rad52/59/22

This superfamily includes proteins related to Rad52. The human Rad52 protein forms a heptameric ring that catalyzes homologous pairing, the essential step of homologous recombination which involves searching for and pairing the homologous regions between single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The RecA protein plays a key role in prokaryotic recombination by promoting the pairing of two DNA molecules at homologous regions. In eukaryotes, homologs of RecA have been identified in many organisms, ranging from yeast to human, including Rad51. There are also ssDNA-annealing proteins that lack sequence homology to the RecA protein that also play essential roles in promoting the homologous pairing reaction, such as Rad52.

Rad52 protein is a recombination enzyme conserved among eukaryotic organisms that plays two distinct roles in homologous pairing. On one side it functions in the initial pairing steps of the Rad51-independent recombination processes but is also serves as a mediator protein in the Rad51-dependent recombination reaction, where it is proposed to facilitate the loading of Rad51 onto the recombination site PMID:12191481.

GO Diversity

Unique GO annotations
56 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1238 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 77
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 10
Unique EC:
Unique GO: 56
Unique Species: 1238