The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

E6 early regulatory protein

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: E6 early regulatory protein

The papillomavirus E6 oncoproteins are small zinc-binding proteins that share a conserved zinc-binding CXXC motif and lack intrinsic enzymatic activity. They are thought to act as adapter proteins, thereby altering the function of E6-associated cellular proteins. This model for E6 function is mostly supported by observations of human papillomavirus type 16 (HPV-16) E6 (16E6), which can alter the metabolism of the p53 tumor suppressor through association with a cellular E3 ubiquitin ligase called E6AP. HPV-16 E6 interacts with an 18-amino-acid sequence in E6AP, which leads to the formation of the E6AP-16E6 complex which in turn binds to p53, inducing the ubiquitin-dependent degradation of the trimolecular complex. It is stated that 16E6 functions as an adapter protein in the complex with p53 because E6AP does not interact with p53 in the absence of E6, hence degradation of p53 requires both E6 and E6AP PMID:26789255,PMID:15664194,PMID:17023019.

GO Diversity

Unique GO annotations
9 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
407 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 14
Domain clusters (>95% seq id): 4
Domain clusters (>35% seq id): 3
Unique PDBs: 7
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 4
Unique EC:
Unique GO: 9
Unique Species: 407