The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Siroheme synthase; domain 2

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Sirohaem synthase, central domain

This superfamily entry represents the central domain (domain II) in the sirohaem synthase. This domain starts with a beta-hairpin that pairs with its two-fold symmetrical partner and forms a second 4-stranded antiparallel beta-sheet that stacks with the first from domain I (NAD+-binding Rossman fold), and then it ends with a bent alpha-helix. The central domain has, along with the N-terminal domain of the enzyme, catalytic activity (precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase), catalysing the biosynthesis of sirohaem.

PFAM:PF14824, INTERPRO:IPR028281,DOI:10.1074/jbc.M710323200PMID:18367445,DOI:10.1093/emboj/21.9.2068PMID:11980703

GO Diversity

Unique GO annotations
16 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
4544 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 21
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 5
Unique PDBs: 7
Structural Clusters (5A): 2
Structural Clusters (9A): 1
FunFam Clusters: 5
Unique EC: 4
Unique GO: 16
Unique Species: 4544