The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Cyanuric acid hydrolase/Barbiturase, RU A

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Cyanuric acid hydrolase/Barbiturase, RU A

Cyanuric acid hydrolases (AtzD) and barbiturases are homologous and found almost exclusively in bacteria. Bioinformatic analysis has revealed a lack of bound metals in this proteins suggesting they do not belong, as it was previously thought, to the amidohydrolase superfamily PMID:22730121. AtzD is involved in cyanuric acid hydrolisis, process that releases carboxybiuret, which spontaneously decarboxylates to biuret, whilst barbituases cleave a single amide bond in the six-membered ring of barbiturate to yield ureidomalonic acid PMID:22730121.

Their structure is comprised of three 'repeating units' (RUs) that share the same structure as one another; they have been designated RU A (residues 3-104), B (residues 113-250) and C (residues 256-364), which, as shown in the PDB, correspond to superfamilies 3.30.1330.170, 3.30.1330.180 and 3.30.1330.160 respectively. Each RU is comprised of a four strand antiparallel beta-sheet and two helices PMID:23651355.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
2 Unique EC terms

Species Diversity

Unique species annotations
418 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 41
Domain clusters (>95% seq id): 6
Domain clusters (>35% seq id): 3
Unique PDBs: 17
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC: 2
Unique GO:
Unique Species: 418