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CATH Superfamily 3.10.20.480

Antirestriction protein ArdA, domain 1

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
Antirestriction protein ArdA, domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Antirestriction protein ArdA, domain 1

This superfamily represents the bacterial antirestriction (ArdA) protein N-terminal domain 1. ArdA functions in bacterial conjugation to allow an unmodified plasmid to evade restriction in the recipient bacterium and yet acquire cognate modification PMID:12618468. ArdA forms a dimer and each monomer is comprised of three small alpha-beta domains, each with a different fold, arranged in a row in each monomer.

This entry represents domain 1 located at the N-terminal end of the monomeric subunit of ArdA. The N-terminal domain consists of a three-stranded anti-parallel beta-sheet and one short alpha-helix interspersed with three large loops of 10 or more residues. Domain 1 is not essential for anti-restriction as it can be deleted, indicating that the key aspect of anti-restriction by ArdA is the binding to the MTase core using domains 2 and 3. PMID:19506028.

PFAM:PF07275,INTERPRO:IPR009899

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
1442 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 4
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 1
Taxonomy
Unique Species: 1442
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