The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:"
The E2 glycoproteins interact with the nucleocapsid through its cytoplasmic domain, while its ectodomain is responsible for binding a cellular receptor. This is an all beta protein belonging to the immunoglobulin superfamily, with three immunoglobulin domains labelled A, B and C in amino- to carboxy-terminal order. Structural domains comprising this superfamily share the structure of the N-terminal domain, known as domain A, of the alphavirus E2 glycoprotein and which is found at the centre of the protein PMID:21124458.
|Domain clusters (>95% seq id):||2|
|Domain clusters (>35% seq id):||2|
|Structural Clusters (5A):||1|
|Structural Clusters (9A):||1|