The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

PINIT domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: PINIT domain

Structural domains comprising this superfamily share the structure of the PINIT domain, found in the Siz/PIAS RING family of SUMO E3 ligases. This proteins present a tripartite architecture with an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING domain, and a C-terminal domain desginated SP-CTD. Structural and biochemical studies have shown that both SP-RING and SP-CTD are required for activation of the E2-SUMO thioester while the PINIT domain is required for redirecting SUMO conjugation to the proliferating cell nuclear antigen (PCNA) at lysine 164, a non-consensus lysine residue that is not modified by the SUMO E2 in the absence of Siz1 PMID:19748360.

GO Diversity

Unique GO annotations
104 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
1140 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 6
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 2
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 21
Unique EC: 1
Unique GO: 104
Unique Species: 1140