The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

D-serine dehydratase-like domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: D-serine dehydratase-like domain

Structural domains comprising this superfamily share the structure of a novel class of D-serine dehydratase, a zinc dependent enzyme involved in the degradation of D-serine, a physiological co-agonist of the NMDA receptor which is thus involved in the regulation of excitatory neurotransmission, important for higher brain functions in vertebrates. The primary structure of the enzyme shows significant similarities to that of metal-activated D-threonine aldolases, fold-type III pyridoxal 5'-phosphate (PLP)-dependent enzymes PMID:21676877, PMID:25715785.

GO Diversity

Unique GO annotations
12 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
4599 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 25
Domain clusters (>95% seq id): 5
Domain clusters (>35% seq id): 4
Unique PDBs: 15
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 19
Unique EC: 4
Unique GO: 12
Unique Species: 4599