The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Efflux pump adaptor protein, beta barrel domain

Periplasmic adaptor proteins are components of bacterial three-component membrane efflux pumps, which are essential for expelling antibiotics, metals and other toxic compounds from bacteria. They are usually multi-domain proteins, in which the domains are arranged in a linear manner: a membrane proximal domain, a beta-barrel domain, a lipoyl domain and an alpha-helical domain.

This superfamily comprises the beta barrel domain and it is found in bacterial drug and metal resistance nodulation cell division (RND)-driven efflux pumps adaptor proteins, such as MexA (from MexAB-OprM efflux pump in Pseudomonas aeruginosa), BesA (from the spirochete Borrelia burgdorferi), CusA (from the CusCBA efflux system), ZneB (the membrane fusion protein component of the ZneCAB efflux complex), MacA (from MacAB-TolC pump), EmrA or AcrA (in E. coli, EmrAB-TolC and AcrA-AcrB-TolC). Structurally, this domain is a beta barrel composed of six to eight beta-strands, and it may contain an alpha-helix situated at entrance to the barrel. It has been suggested that this domain plays a role in binding efflux substrates.

Pfam clan [PfamClan:CL0105],PMID:15117957,PMID:23851070,PMID:23499019,PMID:15226509,PMID:21350490,PMID:20534468,PMID:19254725,PMID:24996185,PMID:22308040

GO Diversity

Unique GO annotations
43 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
14706 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 87
Domain clusters (>95% seq id): 12
Domain clusters (>35% seq id): 8
Unique PDBs: 25
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 78
Unique EC:
Unique GO: 43
Unique Species: 14706