The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Inverse autotransporter, beta-domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Inverse autotransporter, beta-domain

This superfamily includes a beta-barrel porin-like domain found in intimins, invasins and other inverse autotransporters PMID:22658748,PMID:25596886. Intimins and invasins are virulence factors produced by pathogenic Gram-negative bacteria. They carry C-terminal extracellular passenger domains that are involved in adhesion to host cells and N-terminal beta domains that are embedded in the outer membrane.

Intimin is believed to mediate adherence and it is necessary for the production of attaching and effacing lesions on tissue culture cells PMID:2172966. Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells PMID:3304658. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins PMID:10514372.


GO Diversity

Unique GO annotations
4 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
864 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 3
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC:
Unique GO: 4
Unique Species: 864