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CATH Superfamily 2.40.128.380

T3SS negative regulator GrlR

The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:

"
T3SS negative regulator GrlR
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: T3SS negative regulator GrlR

Structural domains comprising this superfamily share the structure of GrlRs, a family of negative regulators of T3SS also involved in lipid binding PMID:19228114.

The locus of enterocyte effacement (LEE) is essential for virulence of enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC). It is comprised of 41 proteins which encode for T3SS proteins in addition to three associated regulators: Ler, GrlA and GrlR. GrlA positively regulates the expression of ler, the first gene in the LEE1 operon, which in turn regulates the expression of various downstream genes involved in T3SS biogenesis. GrlR binds directly to GrlA and functions as an anti-regulator PMID:24092262.

GO Diversity

Unique GO annotations
0 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
286 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 6
Domain clusters (>95% seq id): 2
Domain clusters (>35% seq id): 1
Unique PDBs: 3
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Function
Unique EC:
Unique GO:
Taxonomy
Unique Species: 286
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