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CATH Superfamily 2.30.31.50

Borrelia outer surface protein E/F

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Borrelia outer surface protein E/F
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Borrelia outer surface protein E/F

Borrelia burgdorferi spirochetes, that cause Lyme borreliosis, survive for a long time in human serum due to their ability to succesfully evade the complement system, an important arm of innate immunity. The outer surface protein E (OspE) of B. burgdorferi is required for this since it recruits complement regulator factor H (FH) onto the bacterial surface to evade complement-mediated cell lysis PMID:23658013.

Structural domains comprising this superfamily share the structure of the family of borrelia outer surface protiens E/F, which includes OspE, OspF, and OspEF-related proteins (Erp) PMID:8655548.

GO Diversity

Unique GO annotations
2 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
15 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 11
Domain clusters (>95% seq id): 3
Domain clusters (>35% seq id): 1
Unique PDBs: 7
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Function
Unique EC:
Unique GO: 2
Taxonomy
Unique Species: 15