The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Hepatitis C virus non-structural protein NS2, C-terminal domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Hepatitis C virus non-structural protein NS2, C-terminal domain

This superfamily entry represents the C-terminal domain of hepatitis C virus non-structural protein NS2.

The viral genome is translated into a single polyprotein of about 3000 amino acids. Generation of the mature non-structural proteins relies on the activity of viral proteases. Non-structural protein 2 (NS2) is an zinc-dependent autocatalytic endopeptidase which cleaves at the NS2/NS3 junction PMID:9224925,PMID:9261354. The action of NS3 proteinase (NS3P, INTERPRO:IPR004109), which resides in the N-terminal one-third of the NS3 protein, then yields all remaining non-structural proteins.

NS2 belongs to MEROPS peptidase family C18 (hepatitis C virus endopeptidase 2, clan CM). The fold consists of two subdomains connected by an extended linker: an N-terminal helical domain and a C-terminal beta sheet. Peptidases are active as a homodimer and the two active sites are formed at the dimer interface by His and Glu from one monomer and Cys from the other. The dimer resembles a 'butterfly' with two-fold symmetry along the vertical axis. The N-terminal subdomain of one molecule interacts with the C-terminal subdomain of the other molecule and vice versa PMID:16862121.


GO Diversity

Unique GO annotations
33 Unique GO terms

EC Diversity

Unique EC annotations
4 Unique EC terms

Species Diversity

Unique species annotations
66 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 12
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 1
Unique EC: 4
Unique GO: 33
Unique Species: 66