The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

Arenavirus glycoprotein, zinc binding domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Arenavirus glycoprotein, zinc binding domain

Arenavirus species are endemic in rodent populations worldwide, and some viruses can be transmitted to humans to cause hemorrhagic fevers with up to 30% mortality. Entry of these viruses into its host cell is initiated by the virus envelope glycoprotein (GPC) binding to a host-cell receptor, transferrin receptor 1 (TfR1) in the pathogenic New World viruses and alpha-dystroglycan in the Old World viruses, upon which the virion particle is endocytosed. GPC-mediated fusion of the viral and endosomal membranes is activated by acidic pH in the maturing endosome.

The GPC complex contains a cleaved stable signal peptide (SSP) in addition to the canonical receptor-binding (G1) and transmembrane fusion (G2) subunits. SSP is essential for intracellular transport of the GPC complex to the cell surface and for its membrane-fusion activity.

Structural domains comprising this superfamily share the structure of the zinc binding domain of GPC, available data is derived from studies on Junin arenavirus (JUNV). The face of the domain that contains the two zinc-binding clusters is well conserved among arenaviruses, and cluster II serves as a binding site for Cys-57 in SSP. It is believed that the zinc-mediated anchoring of SSP contributes to positioning the ectodomain loop of SSP relative to the G2 ectodomain to modulate membrane fusion PMID:21068387.

GO Diversity

Unique GO annotations
1 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
57 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 0
Unique EC:
Unique GO: 1
Unique Species: 57