The name of this superfamily has been modified since the most recent official CATH+ release (v4_4_0). At the point of the last release, this superfamily was named:
"Functional Families
Superfamily: Arenavirus glycoprotein, zinc binding domain
The GPC complex contains a cleaved stable signal peptide (SSP) in addition to the canonical receptor-binding (G1) and transmembrane fusion (G2) subunits. SSP is essential for intracellular transport of the GPC complex to the cell surface and for its membrane-fusion activity.
Structural domains comprising this superfamily share the structure of the zinc binding domain of GPC, available data is derived from studies on Junin arenavirus (JUNV). The face of the domain that contains the two zinc-binding clusters is well conserved among arenaviruses, and cluster II serves as a binding site for Cys-57 in SSP. It is believed that the zinc-mediated anchoring of SSP contributes to positioning the ectodomain loop of SSP relative to the G2 ectodomain to modulate membrane fusion PMID:21068387.
GO Diversity
EC Diversity
Species Diversity
Sequence/Structure Diversity
Superfamily Summary
Structures | |
---|---|
Domains: | 1 |
Domain clusters (>95% seq id): | 1 |
Domain clusters (>35% seq id): | 1 |
Unique PDBs: | 1 |
Alignments | |
Structural Clusters (5A): | 1 |
Structural Clusters (9A): | 1 |
FunFam Clusters: | 0 |
Function | |
Unique EC: | |
Unique GO: | 1 |
Taxonomy | |
Unique Species: | 57 |