The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

GPCR, family 3, nine cysteines domain

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: GPCR, family 3, nine cysteines domain

Structural domains comprising this superfamily share the structure of a large hydrophilic extracellular agonist-binding region of the GPCR family 3 receptors (also known as family C) which contains several conserved cysteine residues which are thought to be involved in disulphide bonds. This family includes metabotropic glutamate receptors, GABAB receptors, calcium-sensing receptors, and some taste and pheromone receptors family PMID:17360426.

GO Diversity

Unique GO annotations
214 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
447 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 9
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 58
Unique EC:
Unique GO: 214
Unique Species: 447