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CATH Superfamily 1.20.970.30

eIF4G, eIF4E-binding domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
eIF4G, eIF4E-binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: eIF4G, eIF4E-binding domain

This superfamily represents the eIF4E-binding domain of eIF4G (eukaryotic initiation factor 4G) PMID:14675538. Binding of this domain to its substrate triggers a coupled folding transition where it forms a right-handed helical ring that wraps around the N-terminus of eIF4E.

The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of translation initiation. It interacts with the small ribosomal subunit interacting protein, eIF3, and the eIF4E/cap-mRNA complex in order to load the ribosome onto mRNA during cap-dependent translation.

INTERPRO:IPR022745,DOI:10.1016/S0092-8674(03)00975-9

GO Diversity

Unique GO annotations
20 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
702 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 1
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 1
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 4
Function
Unique EC:
Unique GO: 20
Taxonomy
Unique Species: 702